The clinical characteristics of Chinese patients with unilateral renal agenesis.

Authors:
Qian Xu
Qian Xu
Xiangya Hospital
China
Hangdi Wu
Hangdi Wu
Institute of Nephrology
Lihan Zhou
Lihan Zhou
National University of Singapore
Singapore
Jingyuan Xie
Jingyuan Xie
School of Medicine
China
Wen Zhang
Wen Zhang
School of Computer
Tulsa | United States
HaiJin Yu
HaiJin Yu
Shanghai Jiaotong University
China
Weiming Wang
Weiming Wang
Ruijin Hospital
China
Ying Qian
Ying Qian
Harvard Medical School
United States

Clin Exp Nephrol 2019 Jun 8;23(6):792-798. Epub 2019 Feb 8.

Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: We aimed to investigate the clinical characteristics of Chinese patients with unilateral renal agenesis.

Methods: We enrolled patients with unilateral renal agenesis diagnosed radiologically at the Department of Nephrology from January 2008 to January 2016. Patients with a solitary kidney due to nephrectomy or renal atrophy due to secondary factors were excluded. Clinical data were recorded and analyzed.

Results: In this study, 118 Chinese patients with unilateral renal agenesis were recruited, and the gender ratio (male/female) was 1.11:1. A total of 14 (11.9%) patients had additional abnormalities, 15 (12.7%) had a family history, and 30 (25.4%) presented with renal insufficiency. Kidney length, serum creatinine level and estimated glomerular filtration rate were significantly different between patients with and without family history (P < 0.05, respectively). Gender showed a significant difference between patients with and without other abnormalities. Kidney length and the incidence of proteinuria, hematuria, hypertension, and hyperuricemia were significantly different between patients with and without renal insufficiency. Logistic regression analysis revealed that family history was associated with severe renal failure (OR = 7.11, 95% CI 1.52-33.25).

Conclusion: Renal insufficiency is common in patients with unilateral renal agenesis. Patients with renal insufficiency have shorter kidney lengths and a higher incidence of proteinuria, hypertension, hematuria, and hyperuricemia. Family history is considered a risk factor for severe renal failure.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10157-019-01704-xDOI Listing
June 2019
5 Reads

Publication Analysis

Top Keywords

patients unilateral
16
unilateral renal
16
renal agenesis
12
chinese patients
12
family history
8
characteristics chinese
8
clinical characteristics
8
patients
7
renal
6
ratio male/female
4
gender ratio
4
recruited gender
4
male/female 1111
4
1111 total
4
119% patients
4
patients additional
4
total 119%
4
agenesis recruited
4
clinical data
4
factors excluded
4

References

(Supplied by CrossRef)
Article in Kidney Int
M Pohl et al.
Kidney Int 2002
Article in Pediatr Nephrol (Berlin, Germany)
J Harambat et al.
Pediatr Nephrol (Berlin, Germany) 2012
Article in J Am Soc Nephrol JASN
AS Woolf et al.
J Am Soc Nephrol JASN 2006
Article in Eur J Med Genet
A Wiesel et al.
Eur J Med Genet 2005
Article in BJU Int
AS Woolf et al.
BJU Int 2007
Article in Nat Clin Pract Nephrol
L Kerecuk et al.
Nat Clin Pract Nephrol 2008
Article in Pediatr Nephrol (Berlin Germany)
J Halek et al.
Pediatr Nephrol (Berlin Germany) 2010
Article in Kidney Int
BM Brenner et al.
Kidney Int 1996
Article in Int Urol Nephrol
M Zaffanello et al.
Int Urol Nephrol 2009
Article in Clin J Am Soc Nephrol CJASN
E Wuhl et al.
Clin J Am Soc Nephrol CJASN 2013
Article in Kidney Int
S Sanna-Cherchi et al.
Kidney Int 2009

Similar Publications