Development and testing of a web-based battery to remotely assess cognitive health in individuals with schizophrenia.

Schizophr Res 2019 06 4;208:250-257. Epub 2019 Feb 4.

Department of Psychiatry, University of Minnesota, United States of America.

Cognitive impairment in schizophrenia is often severe, enduring, and contributes significantly to chronic disability. A standardized platform for identifying cognitive impairments and measuring treatment effects in cognition is a critical aspect of comprehensive evaluation and treatment for individuals with schizophrenia. In this project, we developed and tested a suite of ten web-based, neuroscience-informed cognitive assessments that are designed to enable the interpretation of specific deficits that could signal that an individual is experiencing cognitive difficulties. The assessment suite assays speed of processing, sustained attention, executive functioning, learning and socio-affective processing in the auditory and visual modalities. We have obtained data from 283 healthy individuals who were recruited online and 104 individuals with schizophrenia who also completed formal neuropsychological testing. Our data show that the assessments 1) are acceptable and tolerable to users, with successful completion in an average of under 40 min; 2) reliably measure the distinct theoretical cognitive constructs they were designed to assess; 3) can discriminate schizophrenia patients from healthy controls with a fair degree of accuracy (AUROC > 0.70); and 4) have promising construct, convergent, and external validity. Further optimization and validation work is in progress to finalize the evaluation process prior to promoting the dissemination of these assessments in real-world settings.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.schres.2019.01.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544475PMC
June 2019
29 Reads

Publication Analysis

Top Keywords

individuals schizophrenia
12
cognitive
6
schizophrenia
5
degree accuracy
4
sustained attention
4
processing sustained
4
speed processing
4
suite assays
4
assays speed
4
accuracy auroc > 070
4
attention executive
4
socio-affective processing
4
processing auditory
4
healthy controls
4
learning socio-affective
4
controls fair
4
fair degree
4
executive functioning
4
functioning learning
4
assessment suite
4

Similar Publications