Search Our Scientific Publications & Authors

Mol Ther 2021 Feb 23. Epub 2021 Feb 23.

Department of Biomedical Sciences, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Although prime editors are a powerful tool for genome editing, which can generate various types of mutations such as nucleotide substitutions, insertions, and deletions in the genome without double-strand breaks or donor DNA, the conventional prime editors are still limited to its target scopes because of the PAM preference of the spCas9 protein. Here, we described the engineered prime editors to expand the range of their target sites using various PAM-flexible Cas9 variants. Using the engineered prime editors, we could successfully generate more than 50 types of mutations with up to 51. Read More

Dev Biol 2021 Feb 23. Epub 2021 Feb 23.

Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA. Electronic address:

Understanding temporal regulation of development remains an important challenge. Whereas average, species-typical timing of many developmental processes has been established, less is known about inter-individual variability and correlations in timing of specific events. We addressed these questions in the context of postembryonic development in Caenorhabditis elegans. Read More

Arch Pathol Lab Med 2021 Mar;145(3):308-319

From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

Context.—: Point-of-care test (POCT) instruments produce lab results with rapid turnaround times. Based on that fact, emergency department (ED) POCT requests are predicated on the belief that rapid test turnaround times lead to improved care, typically a decreased ED length of stay (LOS). Read More

JMIR Res Protoc 2021 Feb 25. Epub 2021 Feb 25.

Deprtment of Medicine, The University of Melbourne, Royal Melbourne Hospital4th Floor, Clinical Sciences Building, Parkville, AU.

Background: The COVID-19 pandemic has highlighted the central importance of health care workers' (HCWs) mental health and wellbeing for the successful function of the health care system. Few targeted digital tools exist to support hospital HCWs' mental health and none appear to have been led and co-designed by HCWs.

Objective: RMHive is being led and developed by HCWs as a mobile app to support the mental health challenges being posed by COVID-19 to HCWs using experience-based co-design (EBCD) processes. Read More

Dokl Biol Sci 2021 Jan 26;496(1):21-24. Epub 2021 Feb 26.

Moscow State University, 119991, Moscow, Russia.

The study of the anatomy and fine structure of Echiura is of great importance for understanding the biology of these animals, which lead a secretive life and dominate in various benthic communities. The first data on the organization of the siphonal part of the midgut of female Bonellia viridis were obtained by the methods of scanning and transmission electron microscopy. Unusual concentric inclusions similar in the ultrastructure to those described in other animals, e. Read More