A tumor suppressive DNA translocase named FANCM.

Authors:
Jihane Basbous
Jihane Basbous
Laboratoire Instabilité du Génome et Cancer
France
Angelos Constantinou
Angelos Constantinou
University of Lausanne
Switzerland

Crit Rev Biochem Mol Biol 2019 Feb 4;54(1):27-40. Epub 2019 Feb 4.

a Institute of Human Genetics (IGH), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM) , Montpellier , France.

FANCM is named after Fanconi anemia (FA) complement group M. The clinical symptoms of FA include congenital abnormalities, pancytopenia, and cancer proneness. However, recent studies reveal that biallelic inactivation of FANCM does not cause the constellation of FA symptoms, but predisposes patients to cancer and infertility. FANCM is a tumor suppressor gene that encodes a conserved and structure-specific DNA translocase. It controls the outcome of homologous recombination and facilitates DNA replication across a variety of natural and chemically induced obstacles. This review details our current understanding of FANCM as a facilitator of the cellular functions of caretaker proteins, including FA, Bloom syndrome, and Ataxia telangiectasia and RAD3-related proteins, which collectively ensure the maintenance of chromosome stability during DNA replication.

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http://dx.doi.org/10.1080/10409238.2019.1568963DOI Listing
February 2019
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(Supplied by CrossRef)
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Auerbach AD et al.
Exp Hematol 1993
Article in BioRxiv
Byers JS et al.
BioRxiv 2017

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