The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.

Authors:
Blair Armistead
Blair Armistead
Center for Global Infectious Disease Research
Elizabeth Oler
Elizabeth Oler
Johns Hopkins University School of Medicine
Baltimore | United States
Kristina Adams Waldorf
Kristina Adams Waldorf
University of Washington
Lakshmi Rajagopal
Lakshmi Rajagopal
Institute of Biotechnology
Finland

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle 98195, WA, USA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle 98101, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle 98195, WA, USA. Electronic address:

Group B streptococcus (GBS) is a β-hemolytic gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. In addition, vertical transmission of GBS during or after birth results in life-threatening neonatal infections, including pneumonia, sepsis, and meningitis. Although the mechanisms by which GBS traffics from the lower genital tract to vulnerable host niches are not well understood, recent advances have revealed that many of the same bacterial factors that promote asymptomatic vaginal carriage also facilitate dissemination and virulence. Furthermore, highly pathogenic GBS strains have acquired unique factors that enhance survival in invasive niches. Several host factors also exist that either subdue GBS upon vaginal colonization or alternatively permit invasive infection. This review summarizes the GBS and host factors involved in GBS's state as both an asymptomatic colonizer and an invasive pathogen. Gaining a better understanding of these mechanisms is key to overcoming the challenges associated with vaccine development and identification of novel strategies to mitigate GBS virulence.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2019.01.035DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
January 2019
13 Reads

Publication Analysis

Top Keywords

gbs
9
highly pathogenic
8
host factors
8
lower genital
8
genital tract
8
asymptomatic colonizer
8
host niches
8
group streptococcus
8
vertical transmission
4
permit invasive
4
transmission gbs
4
niches host
4
intrauterine space
4
addition vertical
4
gbs birth
4
vagina intrauterine
4
life-threatening neonatal
4
neonatal infections
4
survival invasive
4
birth life-threatening
4

Similar Publications