[Determination of 10 perfluorinated carboxylic acid compounds in water by gas chromatography-mass spectrometry coupled with negative chemical ionization].

Authors:
Xiaoyan Wang
Xiaoyan Wang
University of California
Berkeley | United States
Weijian Shen
Weijian Shen
Huazhong Agricultural University
China
Hong Wang
Hong Wang
State Key Laboratory of Oncogenes and Related Genes
China
Keyao Yu
Keyao Yu
Huazhong Agricultural University
China
Bin Wu
Bin Wu
Ren Ji Hospital
China
Guoshen Hu
Guoshen Hu
Plant and Food Inspection Center
Gongjun Yang
Gongjun Yang
China Pharmaceutical University

Se Pu 2019 Jan;37(1):32-39

College of Pharmacy, Chian Pharmaceutical University, Nanjing 210009, China.

A method was developed for the simultaneous determination of 10 perfluorinated carboxylic acid compounds in water by gas chromatography-mass spectrometry coupled with negative chemical ionization (GC-NCI-MS). Perfluorinated carboxylic acid compounds were derivatized by trifluoro--methyl--(trimethylsilyl) acetamide (MSTFA) as the trimethylsilyl derivatization reagent. The water sample was purified and enriched through a weak anion exchange solid phase extraction column and analyzed via GC-NCI-MS. The sample pretreatment, derivation and instrument conditions were optimized. The results showed that the linearity of the 10 perfluorinated carboxylic acid compounds was good in the range of 0.1-10 mg/L with correlation coefficients of 0.9956-0.9993. The limits of detection (LODs) and limits of quantification (LOQs) were 0.5-1.5 μg/L and 1.5-4.5 μg/L, respectively. The spiked recoveries of the blank samples ranged from 70.2% to 112.6% with the relative standard deviations (RSDs) between 2.1% and 14.5% (=6). The method is simple, sensitive, accurate and precise, and can be used to detect the 10 perfluorinated carboxylic acid compounds in water.

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Source
http://dx.doi.org/10.3724/SP.J.1123.2018.07019DOI Listing
January 2019
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