Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans.

Authors:
Anita K McElroy
Anita K McElroy
United States Army Medical Research Institute of Infectious Diseases
United States
Punya Shrivastava-Ranjan
Punya Shrivastava-Ranjan
Centers for Disease Control and Prevention
United States
Jessica R Harmon
Jessica R Harmon
Centers for Disease Control and Prevention
Atlanta | United States
Timothy D Flietstra
Timothy D Flietstra
Centers for Disease Control and Prevention
Colleen S Kraft
Colleen S Kraft
Emory University School of Medicine
United States
Aneesh K Mehta
Aneesh K Mehta
Emory University School of Medicine
United States

Emerg Infect Dis 2019 02;25(2):290-298

Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. Furthermore, substantial immunoreactivity of host tissues to a CD163-specific antibody, predominantly in areas of extensive immunostaining for Ebola virus antigens, was observed in fatal cases. These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD.

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Source
http://dx.doi.org/10.3201/eid2502.181326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346465PMC
February 2019
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