Facial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: A case report.

Authors:
Kohei Ogawa
Kohei Ogawa
Kyoto University
Japan
Yasuhiro Mitsui
Yasuhiro Mitsui
Kurume University Medical Center
Japan
Yukiko Nakanishi
Yukiko Nakanishi
Fujita Health University School of Health Sciences
Japan
Hiroaki Azukizawa
Hiroaki Azukizawa
Osaka University Graduate School of Medicine
Hideo Asada
Hideo Asada
Nara Medical University
Japan

J Cutan Pathol 2019 May 18;46(5):363-367. Epub 2019 Feb 18.

Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan.

Pustules with facial and/or neck edema is one characteristic feature of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) at the early stage. Although several retrospective histopathologic studies on DIHS/DRESS have been reported, the detailed histopathologic findings of facial pustules for DIHS/DRESS are unavailable. We herein report a case of DIHS/DRESS with facial pustules that was histopathologically similar to eosinophilic pustular folliculitis (EPF). Eosinophilic infiltration into expanded follicles and sebaceous glands, which is highly characteristic of EPF, was detected in pustules due to DIHS/DRESS in this case. There are numerous pathophysiological similarities between DIHS/DRESS and EPF, which may cause their histopathologic similarity. Our findings suggest that facial pustules of DIHS/DRESS may histopathologically mimic EPF.

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http://dx.doi.org/10.1111/cup.13428DOI Listing
May 2019
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