A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia.

Nat Commun 2019 01 21;10(1):358. Epub 2019 Jan 21.

Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, 200438, China.

We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the GRM5/TYR and HERC2/OCA2 genes, respectively) and several epistatic interactions among independently associated alleles. Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated with skin pigmentation in Africans. We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, probably after their split from Europeans.

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Source
http://www.nature.com/articles/s41467-018-08147-0
Publisher Site
http://dx.doi.org/10.1038/s41467-018-08147-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341102PMC
January 2019
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