Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis.

Authors:
Jun Xu
Jun Xu
State Key Laboratory for Biology of Plant Diseases and Insect Pests
Xin Zhao
Xin Zhao
National Key Research Laboratory of Natural and Biomimetic Drugs
Shanwen Sun
Shanwen Sun
The First Affiliated Hospital of Nanjing Medical University
Peng Ni
Peng Ni
Indiana University
United States
Chujun Li
Chujun Li
The First Affiliated Hospital of Sun Yat-sen University of Medical Sciences
China
Anjing Ren
Anjing Ren
Second Military Medical University
Dr. Wei Wang, MD
Dr. Wei Wang, MD
College of Life Science
China
Lingjun Zhu
Lingjun Zhu
The First Affiliated Hospital of Nanjing Medical University
China

J Oncol 2018 18;2018:3720684. Epub 2018 Dec 18.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Homocysteine, a key component in one-carbon metabolism, is of great importance in remethylation. Many epidemiologic studies have assessed the association between homocysteine and risk of digestive tract cancer, but the results are inconsistent.

Objective: The objective of our meta-analysis is to assess the association between homocysteine and digestive tract cancer risk.

Methods: Comprehensive searches were performed on the PubMed, Embase, Cochrane, and Web of Science databases up to September 25, 2018, to identify relevant studies. Thirteen studies were included in the meta-analysis. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of the relationship between homocysteine and the risk of digestive tract cancer.

Results: The pooled OR of digestive tract cancer risk for patients with the highest categories of blood homocysteine levels versus the lowest categories was 1.27 (95% CI, 1.15, 1.39) with no significant heterogeneity observed ( = 0.798, = 0.0%). Moreover, the dose-response analysis revealed that each 5mol/L increase in homocysteine increased the incidence of digestive tract cancer by 7%.

Conclusion: Generally, our results indicated that elevated homocysteine was associated with higher risk of digestive tract cancer. That is, homocysteine concentration may be a potential biomarker for occurrence of digestive tract cancer.

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Source
http://dx.doi.org/10.1155/2018/3720684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312580PMC
December 2018
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References

(Supplied by CrossRef)
Article in Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiology, Biomarkers & Prevention 2004

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