Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats.

Authors:
Eduardo Alexandre Loth
Eduardo Alexandre Loth
Centro de Ciências Exatas e Tecnológicas
Brazil
Vanessa Cecatto
Vanessa Cecatto
Departamento de Fisioterapia
Rodrigo Daniel Genske
Rodrigo Daniel Genske
Departamento de Fisioterapia
Maricilia Silva Costa
Maricilia Silva Costa
Instituto de Pesquisa & Desenvolvimento
Rinaldo Ferreira Gandra
Rinaldo Ferreira Gandra
Centro de Ciências Exatas e Tecnológicas
Brazil
Cleverson Marcelo Pilatti
Cleverson Marcelo Pilatti
Western Parana State University Hospital
Brazil

Rev Soc Bras Med Trop 2019 Jan 14;52:e20180043. Epub 2019 Jan 14.

Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, São José dos Campos, SP, Brasil.

Introduction: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.

Methods: Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.

Results: Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.

Conclusions: Articular arthritic lesions were induced and progressed during the study period in all experimental groups.

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http://dx.doi.org/10.1590/0037-8682-0043-2018DOI Listing
January 2019
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