Nat Commun 2019 01 14;10(1):190. Epub 2019 Jan 14.
Blood Research Institute, Versiti Wisconsin, Milwaukee, WI, USA.
A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgD expression maintains tolerance by, at least in part, promoting CD4Foxp3 regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BD) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. The cell surface phenotype and regulatory function of BD are highly suggestive that they are a new B cell subset. Human splenic and peripheral blood IgD B cells also exhibit BD regulatory activity, rendering them of therapeutic interest.
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