Mature IgD B cells maintain tolerance by promoting regulatory T cell homeostasis.

Authors:
Avijit Ray, PhD
Avijit Ray, PhD
AbbVie
Senior Scientist II
Immunology, Immuno-oncology, Autoimmunity and Inflammation, Immune tolerance
North Chicago, IL | United States
Mohamed I Khalil
Mohamed I Khalil
Stanford University School of Medicine
Stanford | United States
Robert T Burns
Robert T Burns
The University of Tennessee
United States
Sreemanti Basu
Sreemanti Basu
Blood Research Institute
United States
Demin Wang
Demin Wang
Blood Research Institute
United States
Sridhar Rao
Sridhar Rao
Medical College of Wisconsin
United States

Nat Commun 2019 01 14;10(1):190. Epub 2019 Jan 14.

Blood Research Institute, Versiti Wisconsin, Milwaukee, WI, USA.

A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgD expression maintains tolerance by, at least in part, promoting CD4Foxp3 regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BD) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. The cell surface phenotype and regulatory function of BD are highly suggestive that they are a new B cell subset. Human splenic and peripheral blood IgD B cells also exhibit BD regulatory activity, rendering them of therapeutic interest.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-08122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331566PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
January 2019
94 Reads
10.742 Impact Factor

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
February 12, 2019, 11:59 pm EST
twitter
Twitter:
February 12, 2019, 5:23 am EST
twitter
Twitter:
February 11, 2019, 9:54 pm EST
twitter
Twitter:
February 11, 2019, 9:34 pm EST
twitter
Twitter:
February 11, 2019, 2:40 pm EST
twitter
Twitter:
February 11, 2019, 12:00 pm EST
twitter
Twitter:
February 11, 2019, 12:00 pm EST
twitter
Twitter:
February 11, 2019, 12:00 pm EST
twitter
Twitter:
February 11, 2019, 12:00 pm EST
twitter
Twitter:
February 11, 2019, 12:00 pm EST
twitter
Twitter:
January 14, 2019, 10:48 am EST

Publication Analysis

Top Keywords

mature cells
8
regulatory cell
8
population mature
8
exhibit regulatory
8
regulatory activity
8
tolerance promoting
8
cell surface
8
igd cells
8
cell
7
cells
6
regulatory
5
study data
4
cell homeostatic
4
developmental study
4
data cells
4
expressing igd
4
level novel
4
low level
4
igd low
4
analysis developmental
4

References

(Supplied by CrossRef)
Article in J. Exp. Med.
SD Wolf et al.
J. Exp. Med. 1996
Article in J. Immunol.
MK Mann et al.
J. Immunol. 2007
Article in J. Immunol.
A Ray et al.
J. Immunol. 2012
Article in Nat. Immunol.
S Fillatreau et al.
Nat. Immunol. 2002
Article in J. Immunol.
TF Tedder et al.
J. Immunol. 2015
Article in J. Neuroimmunol.
A Ray et al.
J. Neuroimmunol. 2010
Article in J. Clin. Invest.
C Mauri et al.
J. Clin. Invest. 2017
Article in Immunol. Rev.
AY Rudensky et al.
Immunol. Rev. 2011
Article in Int. Immunol.
G Liao et al.
Int. Immunol. 2010

Similar Publications