[Intracranial involvement in newly diagnosed multiple myeloma with TP53 deletion: Two case reports].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1272-1275

Department of Hematology, Fujian Provincial Hospital; Provincial Clinical Medicine College, Fujian Medical University, Fuzhou 350001, China.

We report two rare cases of multiple myeloma (MM) with dural intracranial disease and TP53 deletion. The two patients presented with skull lytic lesion and dural involvement of myeloma. The association between intracranial involvement in MM and TP53 deletion has not been determined. The two patients received bortezomib-based intensive induction and got good response, just as that reported in literature. MM presenting with dural intracranial disease and TP53 deletion at diagnosis is associated with poor outcome. Multi-drug regime containing bortezomib followed by autologous or allogeneic stem cell transportation would improve the prognosis.

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.018DOI Listing
November 2018
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