Despite genetic abnormalities, the hiPSCs showed a positive contribution and efficiently differentiated into 3D retinal organoids. Additionally, the organoids recapitulated retinal neurogenesis and acquired mature photoreceptors, including rod and cone cells.
This report is the first to show that hiPSCs with abnormal chromosomal content are permissive to the generation of three-dimensional retinal organoids.
Cells 2019 01 9;8(1). Epub 2019 Jan 9.
Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan.
Download full-text PDF