Invest Radiol 2016 11;51(11):683-690
From the *Department of Neuroradiology, University of Heidelberg Medical Center; †Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg; ‡Department of Psychology, University of Mannheim, Mannheim; §Central Institute of Mental Health, University of Heidelberg; ∥Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany.
Purpose: Recent studies reported an increase in the dentate nucleus (DN)-to-pons signal intensity (SI) ratio (DN-pons SI ratio) on unenhanced T1-weighted images in patients who received consecutive serial injections of linear gadolinium-based contrast agents (GBCAs). In contrast, most studies found no increase in the DN-pons SI ratio when patients were treated with consecutive serial injections of macrocyclic GBCAs. However, the potential difference between macrocyclic and linear GBCAs has never been assessed in individuals who received subsequent applications of both contrast agents. Read More