The novel lncRNA is pro-neurogenic and mutated in human neurodevelopmental disorders.

Elife 2019 Jan 10;8. Epub 2019 Jan 10.

Center for Personal Dynamic Regulomes, Stanford University, Stanford, United States.

Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy number variation morbidity maps of a cohort of children with autism spectrum disorder/intellectual disability versus healthy controls revealed focal genomic mutations affecting several lncRNA candidate loci. Here we find that a t(5:12) chromosomal translocation in a family manifesting neurodevelopmental symptoms disrupts specifically . We further show that is an evolutionarily conserved lncRNA functionally enhances induced neuronal cell maturation and directly occupies and regulates transcription of neuronal genes including autism-associated genes. Thus, integrating human genetics and functional testing in neuronal lineage induction is a promising approach for discovering candidate lncRNAs involved in neurodevelopmental diseases.

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Source
https://elifesciences.org/articles/41770
Publisher Site
http://dx.doi.org/10.7554/eLife.41770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380841PMC
January 2019
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