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J Photochem Photobiol B 2021 Feb 27;217:112170. Epub 2021 Feb 27.

University of São Paulo, São Carlos Institute of Physics, Brazil.

A combination of metabolic modifications by light stimulus and photodynamic action is very attractive. Photobiomodulation therapy (PBMT) comprehends a vast range of applications and has been shown to be suitable to ease morbidities caused by chemotherapy and radiation, such as mucositis and dermatitis. The current study investigates the effects of near-infrared PBMT combined with porphyrin-based photodynamic therapy (PDT) in squamous cell carcinoma cell lines SCC-25 and SCC-4. Read More

Am J Otolaryngol 2021 Feb 26;42(4):102968. Epub 2021 Feb 26.

Department of Otolaryngology, Children's National Medical Center, Washington, DC, United States of America.

Purpose: Active transcutaneous Bone Conduction Implants (BCIs) are relatively new to the market and may offer improved outcomes while reducing skin-related complications associated with previous models. The purpose of this study is to examine medical device reports (MDRs) submitted to the Food and Drug Administration's (FDA) Manufacturer and User Device Facility Experience (MAUDE) database to identify adverse events with the active, transcutaneous BCIs, Bonebridge and Osia.

Methods: A search of the FDA MAUDE database was conducted using product code "PFO" (for Active Implantable Bone Conduction Hearing System), brand names "Bonebridge" and "Osia. Read More

Am J Otolaryngol 2021 Feb 18;42(4):102989. Epub 2021 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Otolaryngology-Head and Neck Surgery, Xiamen Chang Gung Memorial Hospital, Xiamen, China. Electronic address:

Background: Olfactory dysfunction, such as hyposmia, is a significant symptom of empty nose syndrome (ENS). The efficacy of surgical intervention in olfaction improvements for ENS has not been investigated extensively.

Objective: The aim of this study was to evaluate changes in olfaction after surgical treatment for ENS. Read More

Ann Anat 2021 Mar 3:151715. Epub 2021 Mar 3.

Medical Faculty Carl Gustav Carus Campus, TU Dresden, 01307, Dresden, Germany.

Background: Severe craniofacial and dental abnormalities, typical for patients with progressive Duchenne muscular dystrophy (DMD), are an exellcent demonstration of Melvin L. Moss "functional matrix theory", highlighting the influence of muscle tissue on craniofacial growth and morphology. However, the currently best approved animal model for investigation of this interplay is the mdx-mouse, which offers only a limited time window for research, due to the ability of muscle regeneration, in contrast to the human course of the disease. Read More

Crit Rev Oncol Hematol 2021 Mar 3:103284. Epub 2021 Mar 3.

Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil; Campus Universitário Darcy Ribeiro, Brasília, 70910-900, DF, Brazil; Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, Division of Oral Pathology, Radiology and Medicine, University of Michigan School of Dentistry. Ann Arbor, 48109-1078, MI, USA. Electronic address:

A systematic review (SR) and meta-analysis were conducted to determine the prevalence of PI3K-AKT-mTOR signaling pathway mutations in patients with head and neck cancer (HNC). Overall, 105 studies comprising 8,630 patients and 1,306 mutations were selected. The estimated mutations prevalence was 13% for PIK3CA (95% confidence interval [CI] = 11-14; I = 82%; p < 0. Read More