Anticoagulants is a risk factor for spontaneous rupture and hemorrhage of gallbladder: a case report and literature review.

Authors:
Zhilong Ma
Zhilong Ma
Taizhou Center for Disease Control and Prevention
Bin Xu
Bin Xu
State Key Laboratory of Pollution Control and Resource Reuse
China
Long Wang
Long Wang
Xiangya Hospital
Sumy | Ukraine
Yukan Mao
Yukan Mao
Shanghai Tenth People's Hospital
Bo Zhou
Bo Zhou
State Key Laboratory of Membrane Biology
China
Zhenshun Song
Zhenshun Song
Xijing Hospital
China
Tingsong Yang
Tingsong Yang
Shanghai Tenth People's Hospital
Shanghai | China

BMC Surg 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Background: The spontaneous rupture of the gallbladder is extremely rare, majority of ruptures occur secondary to traumatic injuries. Here, we report a case of spontaneous rupture of the gallbladder with probably cause of oral anticoagulants.

Case Presentation: A 51-year-old woman presented to the emergency room with sudden-onset severe abdominal pain, as well as hypotension and low level of hemoglobin. Abdominal computed tomography (CT) scan showed a 2.5 cm filling defect and discontinuity in the wall of the gallbladder body, and a massive hematocele in the abdominal cavity. Past medical history was significant for hypertension and had been taking daily aspirin for the past three years because of interventional surgery for cerebral aneurysms, but no history of recent abdominal trauma or past episodes of biliary colic. The patient underwent an urgent laparoscopic abdominal exploration and the gallbladder was removed. The pathology just showed chronic cholecystitis and the patient recovered well.

Conclusion: Long-term use of anticoagulants may increase the risk of gallbladder rupture and hemorrhage, which is a lethal condition. Rapid diagnosis and timely surgical intervention are the most important measures to treat the patient.

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Source
http://dx.doi.org/10.1186/s12893-018-0464-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321697PMC
January 2019
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