Associations between inhaled doses of PM-bound polycyclic aromatic hydrocarbons and fractional exhaled nitric oxide.

Chemosphere 2019 Mar 28;218:992-1001. Epub 2018 Nov 28.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. Electronic address:

Exposure to fine particulate matter (PM) is linked to various respiratory outcomes. However, the associations of concentrations of PM-bound polycyclic aromatic hydrocarbons (PM-bound PAHs) with airway inflammatory indices remains unclear. To assess effects of short-term exposure to PM-bound PAHs on fractional exhaled nitric oxide (FeNO), we conducted a pilot study with repeated measures. We recruited 20 postgraduate students in Wuhan city, China, and repeatedly measured outdoor and indoor (including dormitories, offices and laboratories) PM-bound PAHs concentrations, urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) and FeNO levels in the four seasons. Subsequently, we estimated inhaled doses of PM-bound PAHs based on the micro-environmental PM-bound PAHs concentrations, time-activity patterns and referred inhalation rates. We assessed the association of inhaled doses of PM-bound PAHs with FeNO using linear mixed-effects regression models. We found the positive associations of urinary ∑OH-PAHs levels with inhaled doses of indoor PM-bound PAHs (including dormitories and offices) (all p < 0.05). A one-unit increase in inhaled doses of PM-bound PAHs or in urinary concentrations of ∑OH-PAHs was corresponded to a maximum FeNO increase of 13.5% (95% CI: 5.4, 22.2) at lag2 day or of 6.8% (95% CI: 3.4, 10.2) at lag1 day. Inhaled doses of PM-bound PAHs or urinary OH-PAHs was positively related to increased FeNO, they may be accepted as a short-term biomarker of exposure to PAHs in air. Exposure to PM-bound PAHs in indoor air may contribute more to the body burden of PAHs than outdoor air, and exhibited stronger effect on increased FeNO rather than urinary OH-PAHs.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2018.11.196DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
March 2019
3 Reads

Publication Analysis

Top Keywords

pm-bound pahs
28
inhaled doses
16
polycyclic aromatic
12
doses pm-bound
12
aromatic hydrocarbons
12
pm-bound
9
pahs concentrations
8
exhaled nitric
8
nitric oxide
8
including dormitories
8
dormitories offices
8
fractional exhaled
8
pm-bound polycyclic
8
pahs
7
feno linear
4
estimated inhaled
4
postgraduate students
4
pahs feno
4
repeated measures
4
association inhaled
4

Similar Publications