Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.

Blood Cancer J 2018 12 21;9(1). Epub 2018 Dec 21.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (R = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41408-018-0162-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315026PMC
December 2018
28 Reads
2.884 Impact Factor

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
January 15, 2019, 2:33 am EST
twitter
Twitter: Jlepping2013
January 8, 2019, 7:18 am EST
twitter
Twitter: Mgironella
January 6, 2019, 5:32 am EST
twitter
Twitter: TeresaPHlthRes
January 5, 2019, 10:58 pm EST
twitter
Twitter: Queizan
January 5, 2019, 4:53 pm EST
twitter
Twitter: Queizan
January 5, 2019, 4:46 pm EST
twitter
Twitter: AuclairDan
January 5, 2019, 4:16 pm EST
twitter
Twitter: YaksicY
January 5, 2019, 3:49 pm EST
twitter
Twitter: RenoHemonc
January 5, 2019, 12:18 pm EST
twitter
Twitter: Sanz_guille
January 5, 2019, 11:36 am EST
twitter
Twitter: Johnde1MYELOMA
January 5, 2019, 10:35 am EST
twitter
Twitter: Dgermain21
January 5, 2019, 9:16 am EST
twitter
Twitter: Mtmdphd
January 5, 2019, 8:15 am EST
twitter
Twitter: PharmaNGS
January 5, 2019, 7:59 am EST
twitter
Twitter: RamonGarciaSanz
January 5, 2019, 5:46 am EST
twitter
Twitter: Hemasurf
January 5, 2019, 5:39 am EST
twitter
Twitter: C_khandanpour
January 5, 2019, 4:53 am EST
twitter
Twitter: DrRaulCordoba
January 5, 2019, 4:00 am EST
twitter
Twitter: DrLucreciaYSS
January 5, 2019, 3:27 am EST
twitter
Twitter: Diegoah66
January 4, 2019, 11:11 pm EST
twitter
Twitter: Meredith_berger
January 4, 2019, 11:05 pm EST
twitter
Twitter: Adrianapordios
January 4, 2019, 10:45 pm EST
twitter
Twitter: PurveySneha
January 4, 2019, 10:43 pm EST
twitter
Twitter: DrOlaLandgren
January 4, 2019, 10:40 pm EST
twitter
Twitter: Hematologo
January 4, 2019, 10:04 pm EST
twitter
Twitter: Mtmdphd
January 4, 2019, 8:15 pm EST
twitter
Twitter: Queizan
January 4, 2019, 5:37 pm EST
twitter
Twitter: Mrktamai
January 4, 2019, 4:36 pm EST
twitter
Twitter: JCPSaraiva
January 4, 2019, 2:16 pm EST
twitter
Twitter: Profghjackson
January 4, 2019, 1:54 pm EST
twitter
Twitter: Maljurf100
January 4, 2019, 1:53 pm EST
twitter
Twitter: OncoBioMed
January 4, 2019, 1:34 pm EST
twitter
Twitter: Kellyviro
January 4, 2019, 12:57 pm EST
twitter
Twitter: BlueApple500816
January 4, 2019, 12:18 pm EST
twitter
Twitter: Mohty_EBMT
January 4, 2019, 12:10 pm EST
twitter
Twitter: PuenteLori
January 4, 2019, 11:29 am EST
twitter
Twitter: R_adaeva
January 4, 2019, 9:32 am EST
twitter
Twitter: Diegoah66
January 4, 2019, 9:16 am EST
twitter
Twitter: MyelomaTeacher
January 4, 2019, 9:11 am EST
twitter
Twitter: VincentRK
January 4, 2019, 8:12 am EST
twitter
Twitter: RuthClifford5
January 3, 2019, 6:22 pm EST
twitter
Twitter: Bloodwise_res
January 3, 2019, 9:16 am EST
twitter
Twitter: CancerandSoc21C
January 3, 2019, 7:47 am EST
twitter
Twitter: CAMBRIDGE_CEU
January 3, 2019, 4:05 am EST
twitter
Twitter: ChrisWragg8
January 3, 2019, 2:58 am EST
twitter
Twitter: AdamSharpMedOnc
January 3, 2019, 2:47 am EST
twitter
Twitter: CancerWallonia
January 3, 2019, 1:37 am EST
twitter
Twitter: Letranger14
January 2, 2019, 7:16 pm EST
twitter
Twitter: Gemma_north
January 2, 2019, 5:52 pm EST
twitter
Twitter: Clare__turnbull
January 2, 2019, 4:52 pm EST
twitter
Twitter: Siddhartha_kar
January 2, 2019, 3:37 pm EST
twitter
Twitter: Went_thataway
January 2, 2019, 1:41 pm EST
twitter
Twitter: Went_thataway
January 2, 2019, 1:40 pm EST
twitter
Twitter: AuclairDan
January 2, 2019, 1:38 pm EST
twitter
Twitter: BrendaDrumm
January 2, 2019, 12:52 pm EST
twitter
Twitter: TumorBoard
January 2, 2019, 12:51 pm EST
twitter
Twitter: VincentRK
January 2, 2019, 12:50 pm EST
twitter
Twitter: Amit_sud
January 2, 2019, 12:02 pm EST
twitter
Twitter: HoulstonLab_ICR
January 2, 2019, 12:02 pm EST
twitter
Twitter: HoulstonLab_ICR
January 2, 2019, 12:02 pm EST
twitter
Twitter: Amit_sud
January 2, 2019, 12:01 pm EST
twitter
Twitter: OncoBioMed
January 2, 2019, 11:50 am EST

Publication Analysis

Top Keywords

risk loci
12
b-cell malignancies
12
lymphocytic leukaemia
8
chronic lymphocytic
8
myeloma chronic
8
multiple myeloma
8
cll risk
8
genetic correlation
8
loci associate
8
shared aetiology
8
risk
5
b-cell
5
risk risk
4
eqtl hi-c
4
integrating eqtl
4
risk integrating
4
associate cll
4
associate risk
4
malignancies r = 04
4
sets totalling
4

Altmetric Statistics

References

(Supplied by CrossRef)
Article in Am. J. Med.
B Barlogie et al.
Am. J. Med. 1992
Article in Nat. Rev. Immunol.
AL Shaffer et al.
Nat. Rev. Immunol. 2002
Article in Nat. Rev. Cancer
R Kuppers et al.
Nat. Rev. Cancer 2005
Article in Nat. Genet.
D Crowther-Swanepoel et al.
Nat. Genet. 2010
Article in Nat. Commun.
PJ Law et al.
Nat. Commun. 2017
Article in Nat. Genet.
HE Speedy et al.
Nat. Genet. 2014
Article in Nat. Commun
M Went et al.
Nat. Commun 2018
Article in Nat. Commun.
JS Mitchell et al.
Nat. Commun. 2016
Article in Nat. Genet.
P Broderick et al.
Nat. Genet. 2011
Article in Nat. Genet.
D Chubb et al.
Nat. Genet. 2013
Article in Nat. Commun.
B Swaminathan et al.
Nat. Commun. 2015

Similar Publications