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Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial.

Authors:
Aloisa Librando Sandra Cinzia Carlesimo Giorgio Albanese Giuseppe Maria Albanese Raffaele Migliorini Elena Pacella

Int J Ophthalmol 2018 18;11(12):1936-1940. Epub 2018 Dec 18.

Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome 00161, Italy.

Aim: To evaluate the efficacy of 0.1% topical salicylic acid (TSA) to treat iatrogenic chronic blepharoconjunctivitis in patients with primary open angle glaucoma (POAG), treated with topical prostaglandin analogues (TPAs).

Methods: Totally 60 patients were randomly distributed into 3 equal size groups, two of which treated with 0.1% TSA (OMKASA) and 0.1% topical clobetasone butyrate (TCB; VISUCLOBEN) respectively, and one consisting of untreated controls. The parameters taken into account at baseline (T0) and after 30d (T1) of therapy were: conjunctival hyperemia, lacrimal function tests [Schirmer I test and break up time (BUT)] and intraocular pressure (IOP).

Results: Conjunctival hyperemia showed a substantial improvement in both treated groups (<0.001) but not among controls. Similarly, lacrimal function tests displayed an improvement of Schirmer I test in both treated groups (<0.05) and an extension of BUT only in the group treated with 0.1% TSA (<0.05). The IOP increase was statistically significant only in those patients treated with 0.1% TCB (<0.001).

Conclusion: The 0.1% TSA has proved to be an effective anti-inflammatory treatment of blepharoconjunctivitis affecting glaucoma patients on therapy with TPAs, leading to a sizeable decrease of inflammation as well as both quantitative and qualitative improvement of tear film. Furthermore, differently from 0.1% TCB, it does not induce any significant IOP increase.

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http://dx.doi.org/10.18240/ijo.2018.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288534PMC
December 2018

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