Gallstones and incident colorectal cancer in a large pan-European cohort study.

Int J Cancer 2019 Sep 11;145(6):1510-1516. Epub 2019 Jan 11.

School of Public Health, Imperial College London, London, United Kingdom.

Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR = 1.14, 95%CI 0.99-1.31, p = 0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR = 0.81, 95%CI 0.63-1.04, p = 0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex.

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http://doi.wiley.com/10.1002/ijc.32090
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September 2019
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References

(Supplied by CrossRef)
The burden of gallstone disease in Europe
Aerts et al.
Aliment Pharmacol Ther 2003
Gallstones
Njeze et al.
Niger J Surg Off Publ Niger Surg Res Soc 2013
Risk factors for Cholelithiasis
Pak et al.
Gastroenterol Nurs 2016
Symptoms, diagnosis and endoscopic management of common bile duct stones
Caddy et al.
Best Pract Res Clin Gastroenterol 2006
Immunity, inflammation, and Cancer
Grivennikov et al.
Cell 2010
Cholecystectomy and the risk of colorectal Cancer
Shao et al.
Am J Gastroenterol 2005

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