Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.

Authors:
Dr. Seyram Kaali, MD, MPH
Dr. Seyram Kaali, MD, MPH
Kintampo Health Research Centre
Kintampo, Brong-Ahafo Region | Ghana
Darby Jack
Darby Jack
Columbia University
United States
Rupert Delimini
Rupert Delimini
University of Ghana
Katrin Burkart
Katrin Burkart
Humboldt-Universität zu Berlin
Germany

Int J Environ Res Public Health 2018 Dec 22;16(1). Epub 2018 Dec 22.

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown.

Materials And Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored.

Results: LPG users had the lowest CO exposures ( = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (β = -14.84, SE = 6.41, = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG β = 19.34, SE = 9.72, = 0.049), but especially boys (β = 30.65, SE = 14.46, = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes.

Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.

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http://dx.doi.org/10.3390/ijerph16010026DOI Listing

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December 2018
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