Eur Oral Res 2018 Jan 1;52(1):12-19. Epub 2018 Jan 1.
Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, USA.
Purpose: This study aimed to evaluate the initial adhesion morphology and alkaline phosphatase (ALP) activity of murine pre-osteoblastic MC3T3-E1 cells cultured on anatase/rutile mixed-phase TiO thin films with photocatalytical activity with previously confirmed antibacterial properties.
Materials And Methods: Anatase/rutile mixed-phase TiO thin films fabricated by anodization and annealing of cpTi were used to culture MC3T3-E1 cells to evaluate the initial cellular adhesion morphology and ALP activity in vitro.
Results: Compared with MC3T3-E1 cells cultured on cpTi substrates and the control group, cells cultured on anatase/rutile mixed-phase TiO thin films exhibited similar ALP levels after cell culture day 9.
Conclusion: Anodizing and annealing processes fabricate multifunctional surfaces on cpTi with improved osteogenic properties for implants.