Spectrum of bactericidal action of amylmetacresol/2,4-dichlorobenzyl alcohol lozenges against oropharyngeal organisms implicated in pharyngitis.

Int J Gen Med 2018 28;11:451-456. Epub 2018 Nov 28.

Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK,

Purpose: Pharyngitis is commonly caused by a self-limiting upper respiratory tract infection (URTI) and symptoms typically include sore throat. Antibiotics are often inappropriately used for the treatment of pharyngitis, which can contribute to antimicrobial resistance, therefore non-antibiotic treatments which have broad antiseptic effects may be more appropriate. Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) are present in some antiseptic lozenges and have established benefits in providing symptomatic relief and some in vitro antiviral action.

Methods: Seven bacterial species associated with pharyngitis, namely subspecies , and , were exposed to an AMC/DCBA lozenge dissolved in artificial saliva. In vitro bactericidal activity was measured as a log reduction in colony-forming units (CFUs).

Results: Bactericidal activity was recorded against all organisms after 1 minute. Greater than 3 log reductions in CFUs were observed at 1 minute for (log reduction CFU/mL ± SD, 5.7±0.1), (6.1±0.1), (6.5±0.0) and (6.5±0.0), at 5 minutes for (6.3±0.0) and (5.0±0.9) and at 10 minutes for (3.5±0.1).

Conclusion: An AMC/DCBA lozenge demonstrated a greater than 99.9% reduction in CFUs against all tested species within 10 minutes, which is consistent with the time a lozenge remains in the mouth. Patients with uncomplicated bacterial pharyngitis may benefit from the antibacterial action of antiseptic AMC/DCBA lozenges. Furthermore, AMC/DCBA lozenges may be more relevant and appropriate than antibiotics for pharyngitis associated with a self-limiting viral URTI.

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Source
http://dx.doi.org/10.2147/IJGM.S184406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276617PMC

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November 2018
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