Modelling appropriate use of trypanocides to restrict wide-spread multi-drug resistance during chemotherapy of animal African trypanosomiasis.

Authors:
Caroline Mirieri
Caroline Mirieri
Kiboko Zoological Investigations and Efficacy Trials Centre
Nicodemus M Masila
Nicodemus M Masila
Kenya Tsetse and Trypanosomiasis Eradication Council (KENTTEC)
Lillian Wambua
Lillian Wambua
The University of Manchester
United Kingdom
Benard W Kulohoma
Benard W Kulohoma
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Blantyre | Malawi

Parasitology 2018 Dec 20:1-7. Epub 2018 Dec 20.

Centre for Biotechnology and Bioinformatics, University of Nairobi,P.O. Box 30197, Nairobi,Kenya.

Trypanocide resistance remains a huge challenge in the management of animal African trypanosomiasis. Paucity of data on the prevalence of multi-drug resistant trypanosomes has greatly hindered optimal veterinary management practices. We use mathematical model predictions to highlight appropriate drug regimens that impede trypanocide resistance development in cattle. We demonstrate that using drugs in decreasing resistance order results in a negligible increase in number of cattle with resistant infection, in contrast to a more pronounced increase from trypanocide use in increasing resistance order. We demonstrate that the lowest levels of trypanocide resistance are achieved with combination therapy. We also show that increasing the number of cattle treated leads to a progressive reduction in the number of cattle with drug resistant infections for treatments of up to 80% of the cattle population for the combination treatment strategy. Our findings provide an initial evidence-based framework on some essential practices that promote optimal use of the handful of trypanocides. We anticipate that our modest forecasts will improve therapeutic outcomes by appropriately informing on the best choice, and combination of drugs that minimize treatment failure rates.

Download full-text PDF

Source
https://www.cambridge.org/core/product/identifier/S003118201
Publisher Site
http://dx.doi.org/10.1017/S0031182018002093DOI Listing
December 2018
8 Reads

Publication Analysis

Top Keywords

number cattle
12
trypanocide resistance
12
resistance order
8
animal african
8
african trypanosomiasis
8
resistance
6
cattle
5
achieved combination
4
therapy increasing
4
combination therapy
4
resistance achieved
4
lowest levels
4
levels trypanocide
4
increasing number
4
treated leads
4
cattle drug
4
drug resistant
4
resistant infections
4
reduction number
4
progressive reduction
4

References

(Supplied by CrossRef)
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo
Priotto et al.
Journal of Biochemistry and Molecular Biology 2007
Drugs and drug resistance in African animal trypanosomosis: a review
Melaku et al.
European Journal of Applied Sciences 2013

Similar Publications