Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.

Authors:
Yuan Yang
Yuan Yang
West China Hospital
China
Bei Bei Wang
Bei Bei Wang
Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
China
Mohammad Ashfaq
Mohammad Ashfaq
Ruhr University Bochum
Xin Dong Guo
Xin Dong Guo
School of Chemistry and Chemical Engineering
China

Int J Pharm 2019 Feb 13;556:338-348. Epub 2018 Dec 13.

Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

Controlled drug-delivery systems have potential as substitutes for traditional medication systems due to the advantages in safety, efficacy, and patient compliance that these long-acting dosage forms provide. In this context, the present study focus on the development of self-implanted hyaluronic acid (HA) tiny needles that encapsulate ivermectin (IVM)-poly (lactic-co-glycolic acid) (PLGA) microparticles for controlled transdermal IVM release to treat parasitic diseases. The fabricated tiny needles involved matching portable applicator have potentially able for self-administration by patients without intense pain or complexity of current controlled-release devices. The biodegradable IVM-loaded PLGA microparticles were prepared and encapsulated within the tip of dissolving HA tiny needles to achieve high delivery efficiency. The drug loading of tiny needles might be controlled by varying the repeat time of filling or pressing processes. In-vitro tests showed that the tiny needles have sufficient mechanical strength to be inserted into skin within seconds and, next rapidly dissolved to release the loaded drug carriers into subcutaneous tissues for intradermal sustained IVM release. With the in-vivo test in rats, the insertion site recovered barrier property within 3 h. In comparison to traditional hypodermic injection or implantation of controlled-release systems, the proposed polymer tiny needles can be considered as a promising device for controlled transdermal drug delivery.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2018.12.019DOI Listing
February 2019
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