One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.

J Org Chem 2018 12 11;83(24):15323-15332. Epub 2018 Dec 11.

Univ. Paris-Sud, BioCIS, CNRS, University Paris-Saclay, Equipe Labellisée Ligue Contre Le Cancer, F-92296 Châtenay-Malabry , France.

A facile one-pot synthesis of 2-styrylindoles, through Suzuki arylation of ortho-substituted chloroenynes followed by N-cyclization and N-demethylation, has been developed. A variety of 2-styrylindoles were obtained in good to excellent yields and were evaluated for their anticancer properties.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.joc.8b02563DOI Listing
December 2018
101 Reads

Publication Analysis

Top Keywords

synthesis 2-styrylindoles
8
ortho-substituted chloroenynes
8
one-pot synthesis
8
developed variety
4
variety 2-styrylindoles
4
n-demethylation developed
4
n-cyclization n-demethylation
4
arylation ortho-substituted
4
2-styrylindoles good
4
good excellent
4
evaluated anticancer
4
yields evaluated
4
excellent yields
4
suzuki arylation
4
anticancer properties
4
chloroenynes n-cyclization
4
chloroenynes facile
4
2-styrylindoles ortho-substituted
4
facile one-pot
4
2-styrylindoles suzuki
4

Similar Publications