Search Our Scientific Publications & Authors

Stem Cells Transl Med 2021 Feb 24. Epub 2021 Feb 24.

The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts (iReFs) to direct the behavior of the epithelial stem cell niche. During lung development, distal lung fibroblasts, in the form of matrix-, myo-, and lipofibroblasts, form the extra cellular matrix (ECM), create tensile strength, and support distal epithelial differentiation, respectively. During de novo septation in a murine pneumonectomy lung regeneration model, developmental processes are reactivated within the iReFs, indicating progenitor function well into adulthood. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2021 Feb;41(2):264-271

Department of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To assess the effect of salt intake on residual renal function in rats and explore the possible mechanism.

Objective: SD rats were 5/6-nephrectomized to induce chronic renal failure followed by peritoneal dialysis for 4 weeks (=18) or without dialysis treatment (control group; =18). In both groups, the rats were divided into 3 subgroups and were given lowsalt diet (0. Read More

Eur Radiol 2021 Feb 23. Epub 2021 Feb 23.

Department of Radiology, Division of Cardiothoracic Imaging, New York-Presbyterian Hospital - Weill Cornell Medical Center, 525 East 68th Street, New York, NY, 10065, USA.

Objectives: Nonspecific interstitial pneumonia (NSIP) lacks specific diagnostic guidelines or criteria for imaging diagnosis, and the need for more reliable computed tomography (CT) characterization remains. We hypothesized that central paradiaphragmatic middle lobe (ML) involvement is present in most patients with NSIP. The purpose of this study was to evaluate the prevalence of ML involvement and thus to assess its potential as a unique feature of NSIP. Read More

Clin Kidney J 2021 Feb 14;14(2):593-601. Epub 2020 Jan 14.

College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Background: Tubulointerstitial fibrosis is a major pathological feature in chronic kidney disease (CKD) and collagen type III (COL3) is a major component of the renal fibrotic scar. We hypothesized that a dysregulated turnover of COL3 is an important determinant of CKD progression. We assessed the relationship between fragments reflecting active formation (PRO-C3) and degradation (C3M) of COL3 and CKD disease progression and mortality in a prospective cohort of CKD patients. Read More

Clin Kidney J 2021 Feb 11;14(2):516-525. Epub 2020 Aug 11.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Background: Similarities in clinicopathological presentations in immunoglobulin A (IgA) nephropathy and IgA vasculitis with nephritis (IgAVN) raise the question of the utility of the Oxford classification in the latter. The aim of this study was to evaluate the Oxford classification in IgAVN.

Methods: We conducted a retrospective cohort study and meta-analysis following systematic searching of the MEDLINE and Excerpta Medica Database (EMBASE) databases between January 2009 and September 2019. Read More