Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model.

Authors:
Caroline Maria Marcos
Caroline Maria Marcos
São Paulo State University - University Estadual Paulista Araraquara
Brazil
Patricia Akemi Assato
Patricia Akemi Assato
Departamento de Análises Clínicas
Ana Marisa Fusco-Almeida
Ana Marisa Fusco-Almeida
Department of Clinical Analysis
Brazil

Med Mycol 2018 Nov 24. Epub 2018 Nov 24.

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, Departamento de Análises Clínicas, Laboratório de Micologia Clinica, Araraquara, São Paulo, Brasil.

The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.

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November 2018
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