Analysis of Zika virus neutralizing antibodies in normal healthy Thais.

Sci Rep 2018 11 21;8(1):17193. Epub 2018 Nov 21.

Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand.

Zika virus (ZIKV) infections have been reported from all over Thailand, but the number of reported cases remains low, suggesting a degree of immune protection against ZIKV infection. To address this possibility, the presence of ZIKV neutralizing antibodies was determined in serum from 135 healthy Thai adults with a plaque reduction neutralization test (PRNT), and a number of samples were subsequently analyzed for the presence of neutralizing antibodies to dengue virus (DENV) and Japanese encephalitis virus (JEV). Results showed that 70.4% (PRNT ≥ 10), 55.6 (PRNT ≥ 20) or 22.2% (PRNT ≥ 20) of the samples showed neutralizing antibodies to ZIKV. Detailed analysis showed no association between the presence of neutralizing antibodies to other flaviviruses (DENV, JEV) and the presence of ZIKV neutralizing antibodies. These results suggest that the level of ZIKV neutralizing antibodies in the Thai population is enough to dampen the transmission of the virus in Thailand.

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http://dx.doi.org/10.1038/s41598-018-35643-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249253PMC
November 2018
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