Schinus molle essential oil as a potential source of bioactive compounds: antifungal and antibacterial properties.

J Appl Microbiol 2019 Feb 26;126(2):516-522. Epub 2018 Dec 26.

Department of Microbiology and Immunology - Institute of Biosciences, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil.

Aims: The study was focused on the evaluation of antimicrobial activity in vitro of the essential oil (EO) of leaves from Schinus molle against bacteria and fungi of clinical importance in the search for the discovery of new active compounds.

Methods And Results: The chemical composition of the S. molle EO was determined by gas chromatography/mass spectrometry and its antimicrobial effect was verified by broth microdilution method. The major compounds found were β-pinene (25·23%), epi-α-cadinol (21·29%), α-pinene (18·72%), myrcene (11·54%) and sabinene (5·02%). The EO showed significant antifungal activity against Paracoccidioides brasiliensis (39·06 μg ml ), weak action against Cryptococcus neoformans (625 μg ml ) and Trichophyton quinckeanum (625 μg ml ) and was inactive against Candida sp. In the analysis of the antibacterial action, the micro-organisms tested did not show sensitivity.

Conclusions: This study showed a promising result of S. molle volatiles against the fungus P. brasiliensis, which causes paracoccidioidomycosis (PCM), a systemic mycosis of great clinical importance in Latin America.

Significance And Impact Of The Study: The results found here are novel and encourage investigations of the compounds present in this EO, which represents a source of molecules with potential use in the treatment of PCM.

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Source
http://doi.wiley.com/10.1111/jam.14157
Publisher Site
http://dx.doi.org/10.1111/jam.14157DOI Listing

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February 2019
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References

(Supplied by CrossRef)
HPLC analysis of quercetin and antimicrobial activity of comparative methanol extracts of Shinus molle L
Abd-Allah et al.
Int J Curr Microbiol App Sci 2015

Adams et al.
2007
The antibacterial, antifungal, and antioxidant activities of essential oils from different aromatic plants
Al-zubairi et al.
Glob Adv Res J Med Sci 2017

Clinical and Laboratory Standards Institute et al.
2008a

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