Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.

Micromachines (Basel) 2018 Aug 25;9(9). Epub 2018 Aug 25.

Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.

Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges, and we provide design criteria recommendations for enteric microelectrodes.

Download full-text PDF

Source
http://www.mdpi.com/2072-666X/9/9/428
Publisher Site
http://dx.doi.org/10.3390/mi9090428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187697PMC
August 2018
38 Reads

Publication Analysis

Top Keywords

nervous system
8
awake animals
8
single-unit recordings
8
recordings enteric
8
gastrointestinal system
8
enteric
5
single-unit
5
structural physiological
4
physiological gap
4
models excised
4
excised tissue
4
including structural
4
tissue large
4
large physiological
4
animal models
4
system conducted
4
gut nervous
4
enteric gut
4
highlight primary
4
signal quality
4

References

(Supplied by CrossRef)
Separation of the longitudinal muscle of the rabbit’s ileum as a broad sheet
Ambache et al.
J. Physiol. 1954

Similar Publications