Considerations When Designing a Microbiome Study: Implications for Nursing Science.

Authors:
Ana F Diallo
Ana F Diallo
University of Connecticut
San Juan | Philippines
Mark B Lockwood
Mark B Lockwood
University of Illinois at Chicago College of Nursing
Chicago | United States
Stefan J Green
Stefan J Green
Research Resources Center
Davis | United States
Dr. Paule V Joseph, PhD, RN, MS, FNP-BC, CTN-B
Dr. Paule V Joseph, PhD, RN, MS, FNP-BC, CTN-B
National Institute of Nursing Research
Tenure-Track Investigator (Clinical)
N/A
Bethesda , Maryland | United States

Biol Res Nurs 2019 03 8;21(2):125-141. Epub 2018 Nov 8.

3 Sensory Science and Metabolism Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Nurse scientists play an important role in studying complex relationships among human genetics, environmental factors, and the microbiome, all of which can contribute to human health and disease. Therefore, it is essential that they have the tools necessary to execute a successful microbiome research study. The purpose of this article is to highlight important methodological factors for nurse scientists to consider when designing a microbiome study. In addition to considering factors that influence host-associated microbiomes (i.e., microorganisms associated with organisms such as humans, mice, and rats), this manuscript highlights study designs and methods for microbiome analysis. Exemplars are presented from nurse scientists who have incorporated microbiome methods into their program of research. This review is intended to be a resource to guide nursing-focused microbiome research and highlights how study of the microbiome can be incorporated to answer research questions.

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http://dx.doi.org/10.1177/1099800418811639DOI Listing
March 2019
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References

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Article in Microbiological Reviews
Amann R. I. et al.
Microbiological Reviews 1995

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