Novel cellulose-agar hydrogel beads have been generated using green solvent (NaOH/Urea) at low temperature. Adsorptiondesorption kinetic studies of Se(VI) and SeMt were performed using this material. New spectrophotometric determination methods for Se (VI) and SeMt have been developed using resazurin and Pd complexation respectively. Approximately 99.9% Se(VI) could be removed from water by repetitive adsorption at initial concentration 100 mg/L, pH 3.0, temperature 313 K for 30 min, which brings the concentration below the WHO permissible limit. Quantitative adsorption of SeMt was observed at high pH 11. Approximately 55% SeMt could be adsorbed on CAB material at initial concentration 15 mg/L, temperature 288 K and contact time 60 min which is fairly encouraging for drug samples. The kinetic data of Se(VI) adsorption on CAB was described as a combination of chemi and physisorptions and that of SeMt was described as physisorptions with a high adsorption capacity of the CAB composite. The desorption studies indicate that 1MHCl solution was able to desorb nearly all the adsorbed Se(VI) and regenerate the CAB. For SeMt, 0.1 M HCl solution was able to release nearly 52% i.e., 3 to 4 mg/L of the adsorbed SeMt. From complementary ions study it was found that the adsorption of Se(VI) was significantly reduced if As(III), Cr(III) and Hg(II) were also present in the medium.
The newly developed hydrogel may be useful for sustain drug delivery of SeMt compounds for cancer treatment.
Many selenium based drugs have been highlighted in current studies to have high anticancer potentials and also have toxicity towards tumor cells. Controlled release of such Se compounds in living body is therefore very important for effective drug metabolism.Dr. Dhiman Santra, Ph.D.
Int J Biol Macromol 2019 Feb 29;122:395-404. Epub 2018 Oct 29.
Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata 700009, India. Electronic address:
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