Generating cellulose-agar composite hydrogels for uptake-release kinetic studies of selenate and selenomethionine

Dhiman Santra, Kamalika Sen

Overview

Novel cellulose-agar hydrogel beads have been generated using green solvent (NaOH/Urea) at low temperature. Adsorptiondesorption kinetic studies of Se(VI) and SeMt were performed using this material. New spectrophotometric determination methods for Se (VI) and SeMt have been developed using resazurin and Pd complexation respectively. Approximately 99.9% Se(VI) could be removed from water by repetitive adsorption at initial concentration 100 mg/L, pH 3.0, temperature 313 K for 30 min, which brings the concentration below the WHO permissible limit. Quantitative adsorption of SeMt was observed at high pH 11. Approximately 55% SeMt could be adsorbed on CAB material at initial concentration 15 mg/L, temperature 288 K and contact time 60 min which is fairly encouraging for drug samples. The kinetic data of Se(VI) adsorption on CAB was described as a combination of chemi and physisorptions and that of SeMt was described as physisorptions with a high adsorption capacity of the CAB composite. The desorption studies indicate that 1MHCl solution was able to desorb nearly all the adsorbed Se(VI) and regenerate the CAB. For SeMt, 0.1 M HCl solution was able to release nearly 52% i.e., 3 to 4 mg/L of the adsorbed SeMt. From complementary ions study it was found that the adsorption of Se(VI) was significantly reduced if As(III), Cr(III) and Hg(II) were also present in the medium.

Summary

The newly developed hydrogel may be useful for sustain drug delivery of SeMt compounds for cancer treatment.

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Author Comments

Dr. Dhiman Santra, Ph.D.
Dr. Dhiman Santra, Ph.D.
University of Calcutta
Department of Chemistry
Analytical Chemistry
Kolkata, West Bengal | India
Many selenium based drugs have been highlighted in current studies to have high anticancer potentials and also have toxicity towards tumor cells. Controlled release of such Se compounds in living body is therefore very important for effective drug metabolism.Dr. Dhiman Santra, Ph.D.

Resources

PubMed.gov and ScienceDirect
https://doi.org/10.1016/j.ijbiomac.2018.10.199

Generating cellulose-agar composite hydrogels for uptake-release kinetic studies of selenate and selenomethionine.

Authors:
Dr. Dhiman Santra, Ph.D.
Dr. Dhiman Santra, Ph.D.
University of Calcutta
Department of Chemistry
Analytical Chemistry
Kolkata, West Bengal | India

Int J Biol Macromol 2019 Feb 29;122:395-404. Epub 2018 Oct 29.

Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata 700009, India. Electronic address:

Cellulose-agar (CAB) composite hydrogel beads were generated for the uptake-release kinetics studies of Se(VI) and selenomethionine (SeMt) from water medium. The objective of this work is to analyze the surface structure, gel properties, thermal stability and chemical functionalities responsible for the adsorption of Se(VI) and SeMt. We propose here a possible mechanism for the adsorptions. Adsorption isotherms are in good agreement with the Freundlich model, yielding a high adsorption capacity for the CAB composite. Maximum adsorption capacity of Se(VI) and SeMt were found to be 7.083 mg g and 34.639 mg g respectively. The mean free energy of adsorption (E*) value was found to be 0.0423 kJ mol and 0.329 kJ mol of Se(VI) and SeMt respectively. 1 M HCl and 0.1 M HCl were able to desorb Se(VI) and SeMt respectively from CAB. The adsorption of Se(VI) was significantly reduced if As(III), Cr(III) and Hg(II) were present as complementary ions in the medium. Similar studies with pristine cellulose beads (CB) yielded insignificant uptake properties.

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http://dx.doi.org/10.1016/j.ijbiomac.2018.10.199DOI Listing
February 2019
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