The Neuropilin-1 Ligand, Sema3A, Acts as a Tumor Suppressor in the Pathogenesis of Acute Leukemia.

Authors:
Zhi-Gang Yang
Zhi-Gang Yang
Sichuan University
China
Rui-Ting Wen
Rui-Ting Wen
Peking University
China
Kai Qi
Kai Qi
State Key Laboratory of Bioreactor Engineering
Mr. Jun Li, B.S.
Mr. Jun Li, B.S.
Huazhong Agricultural University
China
Gui-Xian Zheng
Gui-Xian Zheng
Guangdong Medical University
Yu-Feng Wang
Yu-Feng Wang
Guangzhou Red Cross Hospital
China
Yu-ming Zhang
Yu-ming Zhang
Nanfang Hospital
China

Anat Rec (Hoboken) 2018 Oct 31. Epub 2018 Oct 31.

Department of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.

Semaphorin-3A (Sema3A) and vascular endothelial growth factor (VEGF165) are ligands of neuropilin-1 (NRP-1 or CD304) and are related to immunoregulation and tumor angiogenesis, respectively. However, possible interactions between NRP-1 and Sema3A and VEGF165 in acute leukemia remain unclear, especially whether Sema3A plays a role in acute leukemia. In this study, both of the proportion of regulatory T cells (Tregs) and their expression of NRP-1 were found to increase in acute leukemia patients compared with healthy controls. In contrast, lower mRNA and plasma levels of Sema3A were detected in the acute leukemia patients. In vitro, the addition of exogenous Sema3A inhibited the expression of NRP-1 on Tregs and it promoted apoptosis of leukemia cells. However, in the presence of anti-Sema3A antibody, the effect of rhSema3A on NRP-1 expression was reversed. These results suggest that Sema3A promotes apoptosis in leukemia cells by inhibiting expression of NRP-1, and thus, represents a tumor suppressor protein with a role in the pathogenesis of acute leukemia. Consequently, NRP-1/Sema3A signaling may represent a novel target for the treatment of acute leukemia and should be further studied. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc.

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http://doi.wiley.com/10.1002/ar.24016
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October 2018
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(Supplied by CrossRef)
Over expression of vascular endothelial growth factor in correlation to Ki-67, grade, and stage of breast cancer
Al-Harris et al.
Saudi Med J 2008
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
Bachelder et al.
Cancer Res 2003

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