The Neuropilin-1 Ligand, Sema3A, Acts as a Tumor Suppressor in the Pathogenesis of Acute Leukemia.

Anat Rec (Hoboken) 2019 07 28;302(7):1127-1135. Epub 2018 Nov 28.

Department of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.

Semaphorin-3A (Sema3A) and vascular endothelial growth factor (VEGF165) are ligands of neuropilin-1 (NRP-1 or CD304) and are related to immunoregulation and tumor angiogenesis, respectively. However, possible interactions between NRP-1 and Sema3A and VEGF165 in acute leukemia remain unclear, especially whether Sema3A plays a role in acute leukemia. In this study, both of the proportion of regulatory T cells (Tregs) and their expression of NRP-1 were found to increase in acute leukemia patients compared with healthy controls. In contrast, lower mRNA and plasma levels of Sema3A were detected in the acute leukemia patients. In vitro, the addition of exogenous Sema3A inhibited the expression of NRP-1 on Tregs and it promoted apoptosis of leukemia cells. However, in the presence of anti-Sema3A antibody, the effect of rhSema3A on NRP-1 expression was reversed. These results suggest that Sema3A promotes apoptosis in leukemia cells by inhibiting expression of NRP-1, and thus, represents a tumor suppressor protein with a role in the pathogenesis of acute leukemia. Consequently, NRP-1/Sema3A signaling may represent a novel target for the treatment of acute leukemia and should be further studied. Anat Rec, 302:1127-1135, 2019. © 2018 Wiley Periodicals, Inc.

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ar.24016
Publisher Site
http://dx.doi.org/10.1002/ar.24016DOI Listing
July 2019
134 Reads
1.530 Impact Factor

Publication Analysis

Top Keywords

acute leukemia
28
expression nrp-1
12
leukemia
9
tumor suppressor
8
pathogenesis acute
8
leukemia cells
8
apoptosis leukemia
8
leukemia patients
8
acute
7
sema3a
7
nrp-1
6
inhibited expression
4
sema3a inhibited
4
exogenous sema3a
4
addition exogenous
4
nrp-1 tregs
4
anti-sema3a antibody
4
promoted apoptosis
4
cells presence
4
presence anti-sema3a
4

References

(Supplied by CrossRef)
Over expression of vascular endothelial growth factor in correlation to Ki-67, grade, and stage of breast cancer
Al-Harris et al.
Saudi Med J 2008
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
Bachelder et al.
Cancer Res 2003

Similar Publications