[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. In particular, the lungs are frequently affected in vasculitis of small vessels, including EGPA, granulomatosis with polyangiitis (GPA), and microscopic polyangiitis (MPA). Among these, EGPA is the most frequent pulmonary eosinophil vasculitis representative. In addition, there are various overlap syndromes in which characteristic features of EGPA can be detected in the context of other anti-neutrophil cytoplasmic antibody (ANCA-)associated vasculitides. Occasionally, non-ANCA-associated pulmonary vasculitides occur with eosinophilia (e.g., Schönlein-Henoch purpura, Kawasaki disease, drug-induced hypersensitivity, and paraneoplastic syndrome). Herein, the pulmonary vasculitides accompanying eosinophilia are presented with respect to both the lung manifestations and pulmonary eosinophilia.

Download full-text PDF

Source
http://link.springer.com/10.1007/s00393-018-0561-z
Publisher Site
http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
24 Reads

Publication Analysis

Top Keywords

granulomatosis polyangiitis
8
pulmonary vasculitides
8
pulmonary
5
polyangiitis gpa
4
gpa microscopic
4
egpa granulomatosis
4
vessels including
4
small vessels
4
microscopic polyangiitis
4
including egpa
4
mpa egpa
4
eosinophil vasculitis
4
vasculitis representative
4
pulmonary eosinophil
4
frequent pulmonary
4
vasculitis small
4
egpa frequent
4
polyangiitis mpa
4
lungs frequently
4
syndrome acute
4

References

(Supplied by CrossRef)
Article in J Asthma
SL Spector et al.
J Asthma 2012
Article in J Allergy Clin Immunol
SJ Szefler et al.
J Allergy Clin Immunol 2012
Article in Lancet Respir Med
DB Price et al.
Lancet Respir Med 2015
Article in Ann Am Thorac Soc
LE Katz et al.
Ann Am Thorac Soc 2014
Article in Am J Clin Pathol
P Winkel et al.
Am J Clin Pathol 1981
Article in J Allergy Clin Immunol
AT Hastie et al.
J Allergy Clin Immunol 2013
Article in Front Immunol
NL Diny et al.
Front Immunol 2017
Article in Front Med (Lausanne)
CN McBrien et al.
Front Med (Lausanne) 2017
Article in Adv Immunol
GJ Gleich et al.
Adv Immunol 1986
Article in Prim Care
A Kovalszki et al.
Prim Care 2016
Article in N. Engl. J. Med.
ME Rothenberg et al.
N. Engl. J. Med. 1998

Similar Publications