Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients.

Authors:
Tatiane Fernanda Sylvestre
Tatiane Fernanda Sylvestre
Tropical Diseases Department - Faculdade de Medicina de Botucatu - Universidade Estadual Paulista (UNESP)
Simone Schneider Weber
Simone Schneider Weber
Laboratório de Biologia Molecular
Bianca Alves Pauletti
Bianca Alves Pauletti
Centro Nacional de Pesquisa em Energia e Materiais
Brazil

PLoS One 2018 25;13(10):e0206051. Epub 2018 Oct 25.

Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Botucatu, São Paulo-Brazil.

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision.

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Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206051PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201901PMC

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April 2019
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References

(Supplied by CrossRef)
Paracoccidioides lutzii sp. nov.: biological and clinical implications
MM Teixeira et al.
Med Mycol 2014
Species boundaries in the human pathogen Paracoccidioides
DA Turissini et al.
Fungal Genet Biol 2017
Paracoccidioidomycosis mortality in Brazil (1980–1995)
ZF Coutinho et al.
Cad Saúde Pública 2002

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