secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort.

Authors:
Meghan B Azad
Meghan B Azad
University of Alberta
Canada
Kaitlin H Wade
Kaitlin H Wade
1] MRC Integrative Epidemiology Unit (IEU) at the University of Bristol
Nicholas J Timpson
Nicholas J Timpson
University of Bristol
United Kingdom

Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. , ) and susceptibility to others (e.g. , ). Non-secretors also have an increased risk of type 1 diabetes and inflammatory bowel disease. We examined genotype, infections and chronic conditions in a population-based cohort. We studied 7,582 pregnant women from the ALSPAC pregnancy cohort. Infections (measles, mumps, chicken pox, whooping cough, meningitis, herpes, gonorrhea and urinary infections) and chronic conditions (kidney disease, hypertension, diabetes, rheumatism, arthritis, psoriasis, hay fever, asthma, eczema and allergies) were self-reported. secretor status was determined from the rs601338 genotype. ABO blood type was obtained from clinical records. Overall, 1920 women (25.3%) were homozygous for the non-secretor allele (AA). Secretor status was associated with mumps, with 68% of non-secretors experiencing this infection, compared to 48% of secretors (RR, 1.40; 95% CI, 1.34-1.46). A weaker association was observed for measles infection (76% vs. 72%; RR, 1.05; 95% CI, 1.02-1.09). Non-secretors also experienced an increased risk of kidney disease (5.4% vs. 3.9%; RR, 1.39; 95% CI, 1.11-1.75). Independent of secretor status, AB blood type was a risk factor for mumps (RR 1.15; 95%CI, 1.03, 1.28 compared to type O). We found no evidence of interaction between secretor status and blood type.  For some conditions, including asthma and arthritis, heterozygosity (GA) appeared to confer an intermediate phenotype. There was no strong evidence of association between secretor status and other infections or chronic conditions, although statistical power was limited for rare outcomes. Our results identify an association between secretor status and self-reported kidney disease, and confirm a recently reported association with susceptibility to mumps infection. The clinical implications of these associations warrant further investigation.

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Source
https://wellcomeopenresearch.org/articles/3-65/v1
Publisher Site
http://dx.doi.org/10.12688/wellcomeopenres.14636.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171556.2PMC
September 2018
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References

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Rotaviruses: From Pathogenesis to Vaccination.
H Greenberg et al.
Gastroenterology. 2009

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