Neuropsychiatric Disorder Associated with Group G Infection.

Authors:
Sawako Yamazaki
Sawako Yamazaki
Niigata City General Hospital
Niigata | Japan
Tsukasa Ohashi
Tsukasa Ohashi
Nishi-Niigata Chuo National Hospital
Japan
Shinichi Magara
Shinichi Magara
Niigata University Graduate School of Medicine and Dental Sciences
Japan
Jun Tohyama
Jun Tohyama
Epilepsy Center
Hiroshi Sakuma
Hiroshi Sakuma
Tokyo Metropolitan Institute of Medical Science
Japan
Masaharu Hayashi
Masaharu Hayashi
Tokyo Metropolitan Institute for Neuroscience
Japan
Akihiko Saitoh
Akihiko Saitoh
University of California
United States

Case Rep Pediatr 2018 23;2018:6047318. Epub 2018 Sep 23.

Department of Pediatrics, Niigata University, Niigata, Japan.

Immune-mediated central nervous system manifestations of group A -hemolytic (GABHS) infection include Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)-which includes tic and obsessive compulsive disorders-and a variety of neurobehavioral disorders. We report a case of subspecies (group G ) (GGS) infection associated with involuntary movements, complex tics, and emotional lability in an 11-year-old Japanese girl. Serum IgM and IgG antibodies to lysoganglioside were positive, and she responded rapidly to intravenous immunoglobulin treatment. Neuropsychiatric disorder associated with GGS infection was ultimately diagnosed. The present findings suggest that neuropsychiatric disorders can result from GGS infection and that the pathogenic mechanism is similar to that of GABHS infection. Future large-scale studies should examine the relation between GGS infection and onset of neuropsychiatric disorder.

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Source
https://www.hindawi.com/journals/cripe/2018/6047318/
Publisher Site
http://dx.doi.org/10.1155/2018/6047318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174767PMC
September 2018
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References

(Supplied by CrossRef)
Article in Clinical Laboratory Science
Clinical Laboratory Science 2003

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