Haem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Eur J Clin Nutr 2019 Aug 18;73(8):1122-1132. Epub 2018 Oct 18.

School of Public Health, Imperial College London, London, UK.

Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding.

Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available.

Results: Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00-1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02-1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case-control subset.

Conclusions: Greater haem iron intake may be modestly associated with lung cancer risk.

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Source
http://dx.doi.org/10.1038/s41430-018-0271-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372073PMC
August 2019
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References

(Supplied by CrossRef)
Article in Lancet
G Danaei et al.
Lancet 2005
Article in Eur Respir J
J Malhotra et al.
Eur Respir J 2016
Article in Ann Oncol
WS Yang et al.
Ann Oncol 2012
Article in Best Pract Res Clin Haematol
ALM Heath et al.
Best Pract Res Clin Haematol 2002
Article in Cancer Res
AJ Cross et al.
Cancer Res 2003
Article in Cancer Epidemiol Biomark Prev
A Fonseca-Nunes et al.
Cancer Epidemiol Biomark Prev 2014
Article in PLoS ONE
J Hooda et al.
PLoS ONE 2013
Article in Nutr Cancer
DH Lee et al.
Nutr Cancer 2005
Article in Eur J Nutr
T Muka et al.
Eur J Nutr 2017
Article in Am J Clin Nutr
N Tasevska et al.
Am J Clin Nutr 2009
Article in Int J Cancer
N Tasevska et al.
Int J Cancer 2011

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