[Prescribing patterns of antiparkinson drugs in a group of Colombian patients, 2015].

Biomedica 2018 09 1;38(3):417-426. Epub 2018 Sep 1.

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma, S.A., Pereira, Colombia.

Introduction: Parkinson's disease, whose prevalence in Colombia is 4.7 per 1,000 inhabitants, is a public health problem and a therapeutic challenge for health professionals.

Objective: To determine the prescribing patterns of antiparkinson drugs and the variables associated with its use in a population from Colombia.

Materials And Methods: We conducted a descriptive cross-sectional study. We selected patients who had been given antiparkinson drugs uninterruptedly between January 1st and March 31st, 2015 from a systematized database of approximately 3.5 million people affiliated to the Colombian health system. We included sociodemographic, pharmacologic and comedication variables. For the multivariate analysis, we used the IBM SPSS™-22 software.

Results: A total of 2,898 patients was included; the mean age was 65.1years, and 50.7% were men; 69.4% (n=2010) of people received monotherapy and 30.6% combination therapy with two to five antiparkinson drugs. The most frequently prescribed drugs were: levodopa 45.5% (n=1,318 patients), biperiden 23.1% (670), amantadine 18.3% (531) and pramipexole 16.3% (471). The most commonly used association was levodopa/carbidopa + entacapone (n=311; 10.7%). Multivariate analysis showed that being male (OR=1.56; 95%CI: 1.321-1.837), over 60 years (OR=1.41; 95%CI 1.112-1.782) and receiving treatment in the city of Barranquilla (OR=2.23; 95%CI 1.675-2.975) were statistically associated with a greater risk of using combination therapy; 68.2% (n=1,977) patients were given concomitant treatment with other drugs.

Conclusions: Prescribing habits of drugs with high therapeutic value predominated, mainly in antiparkinson drugs monotherapy. Most were employed in the usual recommended doses. It is necessary to explore the clinical effectiveness of the medications studied and differentiate between disease and parkinsonian syndromes subtypes.

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http://dx.doi.org/10.7705/biomedica.v38i4.3781DOI Listing
September 2018
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References

(Supplied by CrossRef)
Generalidades de la enfermedad de Parkinson.
Acta Neurol Colomb 2014
Prevalencia de las enfermedades neurológicas en el Valle del Cauca. Estudio Neuroepidemiológico Nacional (EPINEURO).
Takeuchi et al.
Colomb Med 1999
National neuroepidemiological study in Colombia (EPINEURO)
Pradilla et al.
Rev Panam Salud Pública 2003
Descripción de la población de pacientes con enfermedad de Parkinson en un centro médico neurológico en la ciudad de Cali, Colombia.
Diazgranados et al.
Acta Neurol Colomb 2011
Prescribing patterns for Parkinson's disease in a South African patient population.
Gaida et al.
J Appl Pharm Sci 2014

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