Freestanding ultrathin films for separation of small molecules in an aqueous environment.

J Biotechnol 2018 Dec 11;288:48-54. Epub 2018 Oct 11.

Austrian Centre of Industrial Biotechnology, Muthgasse 11, 1190, Vienna, Austria; University of Natural Resources and Life Sciences Vienna, Muthgasse 18, 1190, Vienna, Austria. Electronic address:

Alternative separation methods operating in an aqueous environment are of increasing importance for further progress of molecular separation in life sciences and other industrial sectors working towards a biobased economy. By spincoating, membranes with thicknesses under 100 nm and 20 cm surface area were prepared from an epoxy based resin. For the first time such ultrathin epoxy films were used for the selective separation of small molecules and metabolites within an aqueous environment. Initially, selectivity is demonstrated by the separation of two dyes of similar size (0.7 and 1.4 nm diameter). By variation of the precursor concentrations, both mechanical stability and selectivity for molecular transport are shown to be tunable. The observed transport properties of the different membranes correlated with their biaxial moduli and ultimate tensile strengths which were in the range of 0.3-3.5 GPa and 10-44 MPa, respectively. These observations agreed with the conclusion drawn from FTIR analysis that variations in the covalent crosslinking density determine the emergent properties. Finally, permeation rates for small molecules of industrial relevance were assessed to confirm a size based diffusion cutoff for compounds with hydrodynamic diameters below 2 nm.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01681656183065
Publisher Site
http://dx.doi.org/10.1016/j.jbiotec.2018.10.002DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
December 2018
38 Reads

Publication Analysis

Top Keywords

aqueous environment
12
small molecules
12
separation small
8
separation
5
transport tunable
4
tunable observed
4
tensile strengths
4
molecular transport
4
stability selectivity
4
selectivity molecular
4
observed transport
4
properties membranes
4
biaxial moduli
4
moduli ultimate
4
correlated biaxial
4
membranes correlated
4
ultimate tensile
4
mechanical stability
4
transport properties
4
variation precursor
4

Similar Publications