The Chemistry of Human Exposure to Aluminium.

Adv Exp Med Biol 2018;1091:33-37

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Keele, Staffordshire, UK.

Before it is possible to begin to understand the chemistry of human exposure to aluminium, it is necessary to appreciate a few basic rules. Rule number one tells us that the form of aluminium which is bound by functional groups on biomolecules is its free trivalent aqueous cation, Al. Rule number two tells us that the binding of Al is determined by both thermodynamic and kinetic constraints. Rule number three tells us how essential it is to understand the critical importance of the exposure regime. The application of these simple rules of aluminium chemistry allows us to understand why, for example, not all aluminium salts are equal and not all routes of aluminium exposure are equivalent.

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http://dx.doi.org/10.1007/978-981-13-1370-7_2DOI Listing
June 2019
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References

(Supplied by CrossRef)

C Exley et al.
Trends Biochem Sci 2009

CT Driscoll et al.
Environ Health Perspect 1985

C Exley et al.
Curr Inorg Chem 2012

C Exley et al.
J Theor Biol 1992

RB Martin et al.
Clin Chem 1986

C Exley et al.
J Inorg Biochem 1994

C Exley et al.
Environ Sci-Process Imp 2013

C Exley et al.
Morphologie 2016

E Shardlow et al.
Front Chem 2017

M Mold et al.
Sci Rep 2016

M Mold et al.
Sci Rep 2014

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