The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.

Artif Cells Nanomed Biotechnol 2018 11;46(sup3):S931-S942. Epub 2018 Oct 11.

b Department of Pharmaceutics, State Key Laboratory of Natural Medicines , China Pharmaceutical University , Nanjing , China.

Background: Combinations of natural products with low toxicities using tumor-targeting carriers may improve cancer treatment. The combined parthenolide and ginsenoside compound K (CK) within tLyp-1 liposomes, with the aim of improving the efficacy of lung cancer treatment.

Results: In vitro studies in A549 human pulmonary adenocarcinoma cells demonstrated that parthenolide/CK tLyp-1 liposomes increased reactive oxygen species levels and induced mitochondrial apoptosis. It enters into cells via receptor-mediated uptake and micropinocytosis, followed by endosomal/lysosomal escape. In vivo studies illustrated that it produced a greater antitumor effect than combined administration of these compounds, with minimal toxicity.

Conclusion: The findings of this study indicated that combined application of natural products in nanocarriers could offer attractive therapeutic options.

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Source
https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1
Publisher Site
http://dx.doi.org/10.1080/21691401.2018.1518913DOI Listing
June 2019
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