The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers.

Nat Rev Cancer 2018 11;18(11):696-705

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC) is an expert-curated description of the genes driving human cancer that is used as a standard in cancer genetics across basic research, medical reporting and pharmaceutical development. After a major expansion and complete re-evaluation, the 2018 CGC describes in detail the effect of 719 cancer-driving genes. The recent expansion includes functional and mechanistic descriptions of how each gene contributes to disease generation in terms of the key cancer hallmarks and the impact of mutations on gene and protein function. These functional characteristics depict the extraordinary complexity of cancer biology and suggest multiple cancer-related functions for many genes, which are often highly tissue-dependent or tumour stage-dependent. The 2018 CGC encompasses a second tier, describing an expanding list of genes (currently 145) from more recent cancer studies that show supportive but less detailed indications of a role in cancer.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41568-018-0060-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450507PMC
November 2018
5 Reads

Publication Analysis

Top Keywords

cancer
8
gene census
8
cancer gene
8
2018 cgc
8
cosmic cancer
8
functional mechanistic
4
expansion includes
4
second tier
4
mechanistic descriptions
4
includes functional
4
encompasses second
4
cgc encompasses
4
contributes disease
4
gene contributes
4
genes expansion
4
descriptions gene
4
tier describing
4
complete re-evaluation
4
re-evaluation 2018
4
multiple cancer-related
4

References

(Supplied by CrossRef)

PA Futreal et al.
Nat. Rev. Cancer 2004

MN Patel et al.
Nat. Rev. Drug Discov. 2013

G Koscielny et al.
Nucleic Acids Res. 2017

AH Ramos et al.
Hum. Mutat. 2015

J Eynden Van den et al.
BMC Bioinformatics 2015

MP Schroeder et al.
Bioinformatics 2014

D Tamborero et al.
Bioinformatics 2013

SA Forbes et al.
Nucleic Acids Res. 2017

SA Forbes et al.
Curr. Protoc. Hum. Genet. 2016

B Vogelstein et al.
Science 2013

Similar Publications