Genetic Risk of Alzheimer's Disease: Three Wishes Now That the Genie is Out of the Bottle.

J Alzheimers Dis 2018 ;66(2):421-423

University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA.

The availability and increasing popularity of direct-to-consumer genetic testing for the presence of an APOE4 allelle led the Alzheimer's Foundation of America Medical, Scientific and Memory Screening Advisory Board to identify three critical areas for attention: 1) ensure consumer understanding of test results; 2) address and limit potential negative consequences of acquiring this information; and 3) support linking results with positive health behaviors, including potential clinical trial participation. Improving access to appropriate sources of genetic counseling as part of the testing process is critical and requires action from clinicians and the genetic testing industry. Standardizing information and resources across the industry should start now, with the input of consumers and experts in genetic risk and health information disclosure. Direct-to-consumer testing companies and clinicians should assist consumers by facilitating consultation with genetic counselors and facilitating pursuit of accurate information about testing.

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218128PMC
October 2019
24 Reads

Publication Analysis

Top Keywords

genetic risk
8
genetic testing
8
genetic
6
testing
5
access appropriate
4
participation improving
4
clinical trial
4
trial participation
4
improving access
4
appropriate sources
4
testing process
4
process critical
4
counseling testing
4
genetic counseling
4
sources genetic
4
potential clinical
4
behaviors including
4
limit potential
4
potential negative
4
address limit
4

References

(Supplied by CrossRef)
The right to know and genetic testing
Sheehan et al.
J Med Ethics 2015
Home testing for HIV
Wright et al.
N Engl J Med 2006
Huntington disease: The complexities of making and disclosing a clinical diagnosis after premanifest genetic testing
McCusker et al.
Tremor Other Hyperkinet Mov (NY) 2017
Interventions for improving the adoption of shared decision making by healthcare professionals
Légaré et al.
Cochrane Database Syst Rev 2014

Similar Publications