Hemodynamic Factors Affecting Carotid Sinus Atherosclerotic Stenosis.

Authors:
Ji-Wei Wang
Ji-Wei Wang
Fudan University
China
Jian-Feng Liu
Jian-Feng Liu
Zhejiang Normal University
China
Hui Li
Hui Li
Xiangya Hospital
Sumy | Ukraine
Song-Tao Yang
Song-Tao Yang
Jilin University
China

World Neurosurg 2019 Jan 24;121:e262-e276. Epub 2018 Sep 24.

Department of Neurosurgery, The First Hospital, Shijiazhuang, China.

Purpose: Carotid atherosclerotic plaque occurs predominantly at the outer wall of the carotid sinus, and computational fluid dynamics (CFD) plays an important role in explaining plaque formation. The present study investigated the hemodynamic factors affecting carotid atherosclerotic stenosis.

Methods: Sixteen patients with normal carotid arteries and 16 with symptomatic stenotic carotid sinus underwent 3-dimensional angiographic imaging evaluations and were studied with CFD to simulate the complete 3-dimensional blood flow and hemodynamic parameter distribution in the carotid bifurcations. The hemodynamic parameters, including wall shear stress (WSS), dynamic and total pressure, total pressure gradient, strain rate, velocity, and velocity angle, were investigated.

Results: The atherosclerosis-prone outer lateral walls of the carotid sinus and the external carotid artery at its start had significantly (P < 0.05) low dynamic pressure, WSS, strain rate, and total pressure gradient but high static pressure. The blood flow near these walls with flow separation had significantly (P < 0.05) decreased velocity and dynamic pressures but a high velocity angle. The carotid divider had significantly (P < 0.05) elevated dynamic and total pressure, WSS, strain rate, and total pressure gradient but reduced static pressure. Additional stenosis occurred at the downstream area of stenosis with significantly (P < 0.05) decreased dynamic pressure, WSS, strain rate, and total pressure gradient similar to the wall at the sinus and the start of the external carotid artery.

Conclusion: Significantly decreased vascular WSS, dynamic pressure, strain rate, and total pressure gradient are key to atherosclerotic plaque formation at the carotid sinus.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750183213
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.09.091DOI Listing

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January 2019
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