Probiotic surface adhesins such as Mucus binding proteins are important modulators in host-microbe interactions, which remains unexplored. Here, we dissect the mechanism of this protein's action and also its efficacy as a potential nutraceutical, when used as controlled release microspheres.
We provide insights into the protein mode of action and its efficacy in competitive exclusion of pathogens. This is important because the mechanism is largely unknown and the controlled release formulations of this protein show high delivery and persistence in gut conditions, thereby proving their significance as a potential nutraceutical in prevention from gastrointestinal pathogens.
It was very interesting to work around our central theme that 'non-antibiotic interventions' are urgently needed to prevent gastrointestinal infections. I could get a lot of insights into this protein and its significance in infection prevention, even when used in truncated form. An absolutely satisfying and enriching experience ! Kumar Siddharth Singh
Sci Rep 2018 09 21;8(1):14198. Epub 2018 Sep 21.
Animal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal, 132001, Haryana, India.
Download full-text PDF