Identification of the Human Skeletal Stem Cell.

Authors:
Gunsagar S Gulati
Gunsagar S Gulati
Stanford Stem Cell Biology and Regenerative Medicine Institute
Palo Alto | United States
Rahul Sinha
Rahul Sinha
Chhatrapati Shahuji Maharaj Medical University
India
Michael Lopez
Michael Lopez
Department of Veterans Affairs Healthcare System
Ava C Carter
Ava C Carter
Howard Hughes Medical Institute and Program in Epithelial Biology
Ryan C Ransom
Ryan C Ransom
Stanford School of Medicine
Andreas Reinisch
Andreas Reinisch
Medical University of Graz
Austria

Cell 2018 Sep;175(1):43-56.e21

Department of Surgery, Stanford Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford Medicine, Stanford, CA 94305, USA. Electronic address:

Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing and multipotent human skeletal stem cell (hSSC) that generates progenitors of bone, cartilage, and stroma, but not fat. Self-renewing and multipotent hSSCs are present in fetal and adult bones and can also be derived from BMP2-treated human adipose stroma (B-HAS) and induced pluripotent stem cells (iPSCs). Gene expression analysis of individual hSSCs reveals overall similarity between hSSCs obtained from different sources and partially explains skewed differentiation toward cartilage in fetal and iPSC-derived hSSCs. hSSCs undergo local expansion in response to acute skeletal injury. In addition, hSSC-derived stroma can maintain human hematopoietic stem cells (hHSCs) in serum-free culture conditions. Finally, we combine gene expression and epigenetic data of mouse skeletal stem cells (mSSCs) and hSSCs to identify evolutionarily conserved and divergent pathways driving SSC-mediated skeletogenesis. VIDEO ABSTRACT.

Abstract Video

More than Just the Bare Bones/ Cell September 20, 2018 (Vol. 175, Iss. 1)


Source: Cell Press

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September 2018
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